Research Articles
GelMA Hydrogel Fabrication for Advanced Neural Constructs: A Comprehensive Guide for Researchers
This article provides a thorough, research-oriented guide to Gelatin Methacryloyl (GelMA) hydrogel fabrication for neural tissue engineering.
GalNAc-siRNA Conjugates: A Complete Guide to Targeted Liver Delivery, Mechanism, and Clinical Applications
This comprehensive review explores the transformative role of N-Acetylgalactosamine (GalNAc)-siRNA conjugates in achieving highly specific hepatic delivery for RNA interference (RNAi) therapeutics.
Decoding Beta-Sheet Formation in Peptide Self-Assembly: A Comprehensive FTIR Spectroscopy Guide for Biomedical Researchers
This article provides a detailed guide to using Fourier-Transform Infrared (FTIR) spectroscopy for analyzing beta-sheet formation in peptide self-assembly.
Next-Gen Diagnostics: How FET Biosensors Are Revolutionizing DNA and Protein Detection
This article provides a comprehensive guide to Field-Effect Transistor (FET) biosensors for researchers and drug development professionals.
Nanoparticle-Mediated CRISPR-Cas9 RNP Delivery: A Comprehensive Guide for Therapeutic Development
This article provides a detailed exploration of nanoparticle (NP)-based delivery systems for CRISPR-Cas9 ribonucleoprotein (RNP) complexes.
A Step-by-Step Protocol for CRISPR-Cas9 Delivery Using Non-Viral Lipid Nanoparticles (LNPs): From Formulation to Functional Validation
This comprehensive guide details a contemporary, optimized protocol for the delivery of CRISPR-Cas9 ribonucleoproteins (RNPs) or mRNA using non-viral lipid nanoparticles (LNPs).
Targeting the Unreachable: Advanced CRISPR-Cas9 Delivery Strategies for Neurodegenerative Disease Therapy
This article provides a comprehensive analysis of CRISPR-Cas9 delivery systems specifically engineered for treating neurodegenerative diseases (NDDs) like Alzheimer's, Parkinson's, and Huntington's.
Decoding BBB Tight Junctions: Structural Gatekeepers and Therapeutic Transport Mechanisms in CNS Drug Development
This comprehensive article examines the critical role of blood-brain barrier (BBB) tight junctions as structural and functional gatekeepers, with a focus on transport mechanisms relevant to CNS drug delivery.
Breakthroughs in Blood-Brain Barrier Dysfunction: Pathophysiology, Models & Therapeutic Targets in Neurodegenerative Diseases
This comprehensive review analyzes the critical role of blood-brain barrier (BBB) pathophysiology in neurodegenerative diseases, targeting researchers and drug development professionals.
Breaking Barriers: BBB Disruption Strategies for Glioblastoma Therapy in 2024
This article provides a comprehensive review for researchers and drug development professionals on the critical role of Blood-Brain Barrier (BBB) disruption in brain cancer and glioblastoma treatment.